Dr. Roee Holtzer Studies Cognitive Activity and Walking in Older Adults

Dec 3, 2020 By: yunews

Dr. Roee Holtzer is a professor and director of the Clinical Psychology Health Emphasis Ph.D. program at Ferkauf Graduate School Of Psychology as well as a professor in the Department Of Neurology at Albert Einstein College Of Medicine. He has co-authored a study with Daliah Ross, a Clinical Psychology Ph.D. student at Ferkauf, and Dr. Meltem Izzetoglu, assistant professor in the Department of Electrical and Computer Engineering at Villanova University, in the Nov. 12, 2020, issue of . Titled “Intraindividual Variability in Neural Activity in the Prefrontal Cortex During Active Walking in Older Adults,” the study investigates “intraindividual variability,” or “within-person variability,” in brain activation patterns connected to “gait [in older adults] when performed under experimental conditions that manipulated attention demands.” As Dr. Holtzer points out, intraindividual variability studies like these are important because their results have “been correlated with and utilized as a predictor of clinical outcomes.” Participants in the study were identified from population lists of lower Westchester County, New York, and selected through a process that included interviews as well as neuropsychological, psychological, functional and mobility assessments. They were asked to perform two single tasks (single-task-walk and single-task-alpha) and one dual task (dual-task-walk). In the single-task-walk condition, participants were asked to walk around an electronic walkway at their normal pace. The cognitive task, single-task-alpha, required participants to stand still while reciting alternate letters of the alphabet (“A,” “C,” “E,” etc.) for 30 seconds out loud. In the dual-task-walk condition, participants were instructed to perform the two single tasks at the same time. Their neural activity was measured using functional near-infrared spectroscopy (fNIRS), which Dr. Holtzer explains is a noninvasive, optics-based neuroimaging modality that can assess changes in brain-activation patterns in natural environments under various experimental conditions by using light in the near-infrared range to quantify changes in oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (Hb). The results of the study showed that intraindividual variability in neural activity during active walking was increased in the dual-task condition compared to the two single tasks; moreover, the increase in intraindividual variability in neural activity across task conditions was greater among men and persons with cognitive impairments. Greater within person variability in brain activation patterns when coupled with similar or worse walking performance, as reported in this article, is suggestive of inefficient utilization of brain resources. “The implications of these findings,” said Dr. Holtzer, “for the assessment of older adults at risk of developing mobility and cognitive decline and disability should be examined in future research.”

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